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Background : Schizophrenia is a severely debilitating mental disorder that is characterized by different neurodevelopmental and behavioral abnormalities, with deficits in perception, emotion processing and social functioning. An evidence seems to involve the role of oxidative stress with antioxidant defense system and disturbances in the molecular disease process schizophrenia. Aim : The present study was conducted to verify the oxidative stress status in schizophrenia Methods : Five patients hospitalized in the RSJ dr.Radjiman Wediodiningrat Lawang evaluated using the Brief Psychiatric Rating Scale ( BPRS ) and levels of malondialdehyde ( MDA ) were assessed at 4 weeks after admission. The MDA results in the patients were compared to those of 35-48 years normal age and gender matched control subjects. Results: MDA levels in schizophrenia patients had an average of 728.5 ± 15.35008 whereas MDA levels in normal people have an average of 695 ± 8.94427 . T test results can be seen sig t of 0,003 . Because the value of sig t < 0.05 so that it can be stated that there is a significant difference between MDA levels in schizophrenic patients with normal people . Patients with schizophrenia are known to have an average of MDA levels greater than the normal person . Conclusions : Schizophrenia is a sever psychiatric disorder and since there is an evidence that an excessive free radicals production or oxidative stress may be involved in the pathophysiology of schizophrenic patient.
Keywords : Oxidative Stress, MDA, Schizophrenia.